"In cancer epidemiologic studies, behavioral and observational studies have been conducted in parallel with genome-wide association studies. Cancer researchers widely agree that one-sided research (either behavioral or genomic) cannot completely present the essential risk factors of cancers, so they have conducted interdisciplinary collaborative studies. My molecular genetic epidemiology to incorporate hormonal and behavioral determinants in cancer prevention and prognosis will afford an opportunity for collaboration between the two research areas by its incorporation of the traditional and rigorous epidemiologic strategy into the genetic study approach, to disentangle the complicated effects of gene–environmental/behavioral interactions on cancer." Dr. Su Yon Jung, a researcher with the UCLA School of Nursing, is a cancer epidemiologist with expertise in study design and data quality assurance, statistically analytic approach, interpretation, and evaluation. During her graduate studies at Pittsburgh, Dr. Jung analyzed hospital-based metastatic breast cancer data to identify prognostic factors for breast cancer survival. Dr. Jung completed a post doc in the Department of Epidemiology at the University of Texas MD Anderson Cancer Center. Dr. Jung’s research at UCLA has focused on identifying cancer-related biomarkers associated with obesity as potential strategies for cancer prevention. She incorporates genetic approaches to evaluate the effect of gene-environmental interactions on the pathways connecting the cancer-relevant biomarkers to cancer carcinogenesis. Areas of Scholarly Expertise and Interest Research design, statistical analyses, multivariate modeling, survival, CART, Baron-Kenny approach, genetic association, gene-environmental interaction
Faculty Research and Clinical Expertise
Dr. Jung has a PhD degree from the department of epidemiology, University of Pittsburgh, and completed a post doc in the department of epidemiology at the University of Texas MD Anderson Cancer Center. During her graduate studies in Pittsburgh and later, she accumulated an array of research experiences using a hospital-based metastatic breast cancer cohort data to identify prognostic factors for breast cancer survival. Her research interests include a focus on identifying cancer-related biomarkers associated with obesity as potential strategies for cancer prevention. She has incorporated genetic approaches to evaluate the effect of gene-environmental interactions on the pathways connecting cancer-relevant biomarkers to cancer carcinogenesis.
University of Pittsburgh, Gradaute School of Public Health PhD, 2010, Epidemiology
The Catholic University of Korea, Graduate School of Public Health, MPH, 2002, Public Health
The Catholic University of Korea, College of Nursing BSN, 1993, Nursing
- Registered Profession Nurse, California State Board, 2015
- Registered Professional Nurse, New York State Board, 2005
- Registered Nurse, Korean Nurses Association, 1993
HONORS AND AWARDS
- NIH K01 NR017852, Principal Investigator, 05/10/2019 – 04/30/2022
- UC Cancer Research Coordinating Committee (CRCC) grant (CRN-18-522722) for 2018-2019 academic year, 2018
- The 2016 Obesity Society Annual Scientific Meeting, Obesity & Caner Section & American Institute for Cancer Research Poster Competition Winner, New Orleans, LA, 2016
- UCLA Hellman Fellows Award for 2016-17 academic year, 2016
- UCLA Faculty Career Development Award for 2015-16 academic year, 2015
- Scholar-in-Training Award, The 12th Annual International Conference on Frontiers in Cancer Prevention Research, American Association of Cancer Research, National Harbor, MD, 2013
- Fellowship recipient (NCI R21), Department of Epidemiology, Division of Cancer Prevention and population sciences, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2012
- Scholarship recipient, Master of Public Health, Graduate School of Public Health, The Catholic University of Korea, Seoul, Korea, 2000
PUBLICATIONS Peer-Reviewed Original Research Articles
- Jung SY, Papp JC, Sobel EM, Zhang ZF. Post Genome-Wide Gene-Environment Interaction Study Using Random Survival Forest: Insulin Resistance, Lifestyle Factors, and Colorectal Cancer Risk. Cancer Prev Res (Phila). 2019 Dec;12(12):877-90.Epub 2019 Sep 25.
- Liu X, Baecker A, Wu M, Zhou JY, Yang J, Han RQ, Wang PH, Liu AM, Gu X, Zhang XF, Wang XS, Su M, Hu X, Sun Z, Li G, Jin ZY, Jung SY, Mu L, He N, Lu QY, Li L, Zhao JK, Zhang ZF. Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China. Nutrients. 2019 Aug;11(9). doi: 10.3390/nu11092038
- Liu X, Baecker A, Wu M, Zhou JY, Yang J, Han RQ, Wang PH, Jin ZY, Liu AM, Gu X, Zhang XF, Wang XS, Su M, Hu X, Sun Z, Li G, Fu A, Jung SY, Mu L, He N, Li L, Zhao JK, and Zhang Z. Family history of liver cancer may modify the association between HBV infection and liver cancer in a Chinese population. Liver International. 2019 Aug; 39(8): 1490-1503. Epub 2019 Jul 10.
- Jung SY and Zhang Z. The effects of genetic variants related to insulin metabolism pathways and the interactions with lifestyles on colorectal cancer risk. Menopause. 2019 Jul; 26(7):771-780.
- Jung SY, Mancuso N, Papp JC, Sobel EM, and Zhang Z. Post genome-wide gene-environment interaction study: the effect of genetically driven insulin resistance on breast cancer risk using Mendelian randomization. PLoS One. 2019 June; 14(6):e0218917.
- Jung SY, Papp JC, Sobel EM, Yu H, and Zhang Z. Breast cancer risk and insulin resistance: post genome-wide gene-environment interaction study using a random survival forest. Cancer Research. 2019 Mar: 79(10):2784-2794. Epub 2019 Apr 1.
- Jung SY, Mancuso N, Yu H, Papp J, Sobel E, and Zhang Z. Genome-wide meta-analysis of gene-environmental interaction for insulin-resistance phenotypes and breast cancer risk in postmenopausal women. Cancer Prevention Research. 2019 Jan; 12(1):31-42. Epub 2018 Oct 16.
- Jung SY, Papp JC, Sobel EM, and Zhang Z. Genetic variants in metabolic signaling pathways and their interaction with lifestyle factors on breast cancer risk: A random survival forest analysis. Cancer Prevention Research. 2018 Jan;11(1):44-51. Epub 2017 Oct 26.
- Jung SY, Ho G, Rohan T, Strickler H, Bea J, Papp JC, Sobel EM, Zhang Z, and Crandall CJ. Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk.. PLoS One. 2017 Oct;12(10):e0186296
- Jung SY, Ho G, Rohan T, Strickler H, Bea J, Papp JC, Sobel EM, Zhang Z, and Crandall CJ. Interaction of insulin-like growth factor-I and insulin resistance–related genetic variants with obesity and lifestyle factors on postmenopausal breast cancer risk. Breast Cancer Research and Treatment. 2017 Jul; 164(2):475-495. E-pub 2017 May 6.
- Jung SY, Sobel EM, Papp JC, and Zhang Z. Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal women. BMC Cancer. 2017 Apr; 17(1):290. [Epub ahead of print]
- Jung SY, Barrington WE, Lane DS, Chen C, Chlebowski R, Corbie-Smith G, Hou L, Zhang Z, Paek M, and Crandall CJ. Bioavailable insulin-like growth factor-I as mediator of racial disparity in obesity-relevant breast and colorectal cancer risk among postmenopausal women. Menopause. 2017 Mar; 24(3):288-298.
- Jung SY, Sobel EM, Papp JC, Crandall CJ, Fu AN, and Zhang Z. Obesity and associated lifestyles modify the effect of glucose metabolism-related genetic variants on impaired glucose homeostasis among postmenopausal women. Genetic Epidemiology. 2016 Sep; 40(6):520-530. E-pub 2016 Jul 5.
- Jung SY, Vitolins MZ, Fenton J, Frazier-Wood AC, Hursting S, and Chang S. Risk profiles for weight gain among postmenopausal women: a classification and regression tree analysis approach. PLoS One. 2015 Mar: e0121430.
- Frazier-Wood AC*, Kim J*, Davis J, Jung SY, and Chang S. In cross-sectional observations, dietary quality is not associated with CVD risk in women; in men, the positive association is accounted for by BMI. British Journal of Nutrition. 2015 Apr; 113(8):1244-1253. E-pub 2015 Mar 27.
- Jung SY, Vitolins MZ, Paskett ED, and Chang S. Exogenous estrogen as mediator of racial differences in bioactive insulin-like growth factor-I levels among postmenopausal women. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2015 Apr; 70(4):495-502. E-pub 2014 Sep 18.
- Jung SY. Challenges in epidemiological and statistical evaluations of effect modifiers and confounders. Frontiers in Public Health, Epidemiology Section. 2014 Dec; 2(227):1-2.
- Jung SY*, Paxton RJ*, Vitolins MZ, Fenton J, Paskett ED, Pollak M, Hays-Grudo J, Hursting S, and Chang S. Associations between time spent sitting and cancer-related biomarkers in postmenopausal women: an exploration of effect modifiers. Cancer Causes & Control. 2014 Nov; 25(11):1427-1437. E-pub 2014 Sep 20.
- Jung SY, Hursting S, Guindani M, Vitolins MZ, Paskett ED, Chang S. Bioavailable insulin-like growth factor-I inversely related to weight gain in postmenopausal women regardless of exogenous estrogen. Cancer Epidemiology, Biomarkers & Prevention. 2014 Mar; 23(3):534-544. E-pub 2013 Dec 20.
- Davis JS, Jung SY, and Chang S. High- and low-fat dietary intake, recurrence, and mortality after breast cancer diagnosis: Kroenke CH, Kwan ML, Sweeney C, et al. Journal of the National Cancer Institute. 105:616-623, 2013. Breast Diseases: a YB Quarterly. 2013 Dec; 24(4):326-327.
- Jung SY*, Rosenzweigh MQ*. Sequential metastatic breast cancer chemotherapy: should the median be the message? Frontiers in Public Health. 2013 Nov; 1(49):1-7.
- Van Panhuis WG, Grefenstette J, Jung SY, Chock NS, Cross A, Eng H, Lee BY, Zadorozhny V, Brown S, Cummings D, and Burke DS. Contagious diseases in the United States from 1888 to the present. The New England Journal of Medicine. 2013 Nov; 369(22):2152-8.
- Jung SY, Rosenzweig MQ, Linkov F, Brufsky A, Weissfeld JL, and Sereika SM. Comorbidity as a potential mediator of survival disparity between younger and older women diagnosed with metastatic breast cancer. Hypertension. 2012 Feb; 59(2):205-211. E-pub 2011 Dec 19.
- Jung SY, Rosenzweig MQ, Sereika SM, Linkov F, Brufsky A, and Weissfeld JL. Factors associated with mortality after breast cancer metastasis. Cancer Causes & Control. 2012 Jan; 23(1):103-12. E- pub 2011 Oct 29.
- Jung SY, Sereika SM, Linkov F, Brufsky A, Weissfeld JL, and Rosenzweig MQ. The effect of delays in treatment for breast cancer metastasis on survival. Breast Cancer Research and Treatment. 2011 Dec; 130(3):953-64. E-pub 2011 Jul 8.
- Jung SY. Comparison of medical expenses of uterus and adnexa uteri operation according to the differences of surgery method in DRG payment system. Journal of Medical Insurance Review Nurses Association. 2002; 8:34-49.
- Jung SY, Lim JH, Yum HY. A study of effectiveness of nursing for lung cancer patients. The Journal of Catholic Nursing. 1993; 10:77-93.
- American Association for Cancer Research, Molecular Epidemiology Working Group, Member, 2013-present
- American Society Preventive Oncology, Member, 2013-present
- The Obesity Society, Member, 2012-present
- Society for Epidemiologic Research, Member, 2011-present
- UCLA Jonsson Comprehensive Cancer Center, Member, 2014 - present
- National Postdoctoral Association, Member, 2013-14