Location: 5-659 Factor Bldg
Phone: (310) 206-0589
“It’s one thing to manipulate conditions in a fume hood or petri dish, but when you’re dealing with human beings, there are many other factors involved—their diet, their stress level, how they respond to medication, etc. I concluded that the way to ensure my research translated well to patients was to become a clinician, so that I could see the outcomes of the research through my patient encounters. I chose nursing because it deals with the complete individual—mind, body, spirit.”
Dr. Nalo Hamilton is a assistant professor with the UCLA School of Nursing. While earning her Ph.D. in Biochemistry, she studied factors controlling the regulation of BRCA1 and BRCA2, which are genes associated with inherited breast cancer. She then obtained a Master’s in Nursing, and became a nurse practitioner. At UCLA, Dr. Hamilton is investigating the regulatory effects of the insulin-like growth factor-II (IGF-2) on gene expression in estrogen receptor negative (ER-) breast cancer cell lines and tumors. Dr. Hamilton believes that her research will help the medical community to fully understand the cascade of events in breast cancer development among a broad spectrum of ethnic groups, to better develop therapeutic agents that target cellular/molecular events in aggressive breast cancer.
Areas of Scholarly Expertise and Interest
Breast cancer, IGF-2, estrogen receptor negative, ER-, BRCA1, BRCA2
Research: The focus of Dr. Hamilton's research is breast cancer development. Currently, she is investing the regulatory affects of the insulin like growth factor-II (IGF-2) on gene expression in estrogen receptor negative (ER-) breast cancer cell lines and tumors.
Clinical: OB and Primary Care; Certified women's health and adult health nurse practitioner
N211 - Theoretical Foundations of Women's Health Care during the Reproductive Years
N429 - Family Nurse Practitioner Practicum 1
2004 - 2007 National Black Nurses Association, Charter Member Nashville Chapter
2008 - 2010 Policy Chair, National Association of Nurse Practitioners (NPWH)
Oakwood (College) University, BS, 1995, Biochemistry
Meharry Medical College, PhD, 2003, Biochemistry
Vanderbilt University, 2005, Nursing
2011-2014 Robert Wood Johnson Nurse Faculty Scholar
2002 National Science Foundation (NSF) Fellow
2002 Co-winner, Vanderbilt-Ingram Cancer Center Poster Competition
2000 American Association for Cancer Research Minority Scholar Award
Hamilton, N., Marquez-Garban, D., Fernando, G., Elshimali, Y., Mah, V., Vadgama, J., Goodglick, L., Pietras, R. (2015) Biologic Roles of Estrogen Receptor –β and Insulin-Like Growth Factor-2 in Triple-Negative Breast Cancer. BioMed Res Intl. 2015:925703
Davis, C., Myers, H., Brecht, L., Nyamathi, A., Lewis, M. A., Hamilton, N. (2014) Bio-psychosocial predictors of psychological functioning among African American breast cancer survivors. J of Psychosocial Oncology. 32(5): 493-516
Richardson, A. E., Hamilton, N., Davis, W., Brito, C., De Leon, D. (2011) Insulin-like Growth Factor-2 (IGF-2) Activates Estrogen Receptor-α and -β via the IGF-1 and the Insulin Receptors in Breast Cancer Cells. Growth Factors. 29(2-3):1-12
Gamble KL, Motsinger-Reif AA, Hida A, Borsetti HM, Servick SV, Ciarleglio CM, Robbins S, Hicks J, Carver K, Hamilton N, Wells N, Summar ML, McMahon DG, Johnson CH.(2011).Shift work in nurses: contribution of phenotypes and genotypes to adaptation. PLoS One, 6, e18395.
Ciarleglio, C. M., Ryckman, K. K., Servick, S. V., Hida, A., Robbins, S., Wells, N., Hicks, J., Larson, S. A., Wiedermann, J. P., Carver, K., Hamilton, N., Kidd, K. K., Kidd, J. R., Smith, J. R., Friedlaender, J., McMahon, D. G., Williams, S. M., Summar, M. L., Johnson, C. H. (2008) Genetic differences inhuman circadian clock genes among worldwide populations. J Biol Rhythms. 23(4): 330-40.
Tripathi, M. K., Misra, S., Khedkar, S.V., Hamilton, N., Irvin-Wilson, C., Sharan, C., Sealy, L., and Chaudhuri, G. (2005) Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells. J Biol Chem. 280(17): 17163-17171.
Sharan, C., Hamilton, N., Parl, A. K., Singh, P. K., and Chaudhuri, G. (1999) Identification and characterization of a transcriptional silencer upstream of the human BRCA2 gene. Biochem. Biophys. Res. Commun. 265(2) pp. 285-290.