The term "vulnerable populations," refers to social groups with increased relative risk (i.e. exposure to risk factors) or susceptibility to health-related problems. This vulnerability is evidenced in higher comparative mortality rates, lower life expectancy, reduced access to care, and diminished quality of life. VPs are often discriminated against, marginalized and disenfranchised from mainstream society, contributing to their lower social status and lack of power in personal, social, and political relationships. The CVPR focuses on two groups identified as particularly vulnerable to health disparities: ethnic/racial minorities and people living in poverty. CVPR investigators and affiliates are advancing knowledge about VPs and methods to eliminate/reduce health disparities. By building on community strengths, relevant interventions are developed to assist communities in identifying and accessing resources to reduce health disparities.