For the last decade, de Peralta has been a cardiology nurse practitioner at the VA Greater Los Angeles Healthcare System, with responsibilities for managing outpatients and inpatients with cardiac and internal medicine needs. The VA system offers extensive support for nurse practitioners, affording a great deal of autonomy. De Peralta serves as co-chair for advanced practice nurses at the VA, and co-chairs an advanced practice nurses review board overseeing the credentialing and peer-review process for the system’s 80-plus nurse practitioners. She has also been involved as a statewide legislative liaison for the California Association for Nurse Practitioners. De Peralta has been active in research, presenting abstracts at national and regional meetings; and lectures on cardiac conditions to residents, fellows, nurse practitioners, and other nurses both within the VA and in the community. She has served as a preceptor for nursing students at UCLA and Case Western University.