Blood-Siegfried, an associate clinical professor at Duke University School of Nursing, has been concerned with the health of infants and children in the clinical setting for more than 30 years. Over the course of her clinical career as a nurse practitioner she became interested in the developmental changes in neonates following birth and how they are affected by environmental insults. Her current focus of study involves the immune and neurobiologic factors associated with sudden infant death syndrome. Blood-Siegfried was a fellow and guest researcher at the National Institute of Environmental Health Sciences from 1998 to 2004 and currently has a major grant from the National Institute of Nursing Research to examine the effects of perinatal nicotine exposure on the development of protective autonomic responses in suckling rats. In addition to her research, she teaches pathophysiology and pediatric primary care to graduate nursing students at Duke and maintains a clinical practice as a pediatric nurse practitioner in a rural community in North Carolina.